One blocked enzyme, two roads, and the lab pattern that tells you which one is closed. This works the pathway on the board — methionine to SAM to SAH to homocysteine, and then the two things the body can do with homocysteine once it's there. When CBS is blocked, homocysteine piles up and methionine climbs with it, which is why a high homocysteine alone doesn't tell you anything and the methionine does. Also covers how homocysteine damages fibrillin at the disulfide bonds, and why cysteine becomes an essential amino acid in these patients. For the brain that needs it different.
Four findings and one lab that separate homocystinuria from Marfan. Both give you a tall patient with long limbs, long fingers, and a dislocated lens, so you can't call it by looking. But the lens goes a different direction in each one, the joints go a different direction, and only one of them clots. This walks the four discriminators — lens, joints, brain, vessel — and then the lab pattern that confirms it. Including why a high homocysteine alone doesn't tell you anything, and why the methionine is the number that does. For the brain that needs it different.
Acid-base doesn't have to be memorized. In about fourteen minutes we build blood gas interpretation from scratch — two chemicals, two organs, and a method you can run on any ABG without a chart. No mnemonics, no memorized tables.
Anaphylaxis does two things to your blood vessels: wide and leaky. Everything else — the hives, the tight throat, the racing pulse, the eighty over forty — falls out of those two words. Plus why the swelling at the ankles is the missing blood pressure.
Back after a long break. I was sick, and getting better took longer than I planned. Thank you for waiting. This episode is the five causes of acute vision loss, and it starts with the one question that splits the differential in half before you look in the eye: is it painful or painless. Only one of the five hurts.
Is BMI real science? Do diets actually work? And why does losing weight so often feel like a fight you keep losing? This episode pulls apart the myths we've all been handed about weight, where that infamous number even came from, and why shame has never made anyone healthier. My husband sat in this time to bring his own point of view, and we go back and forth on the part that usually gets left out, that wanting to lose weight is completely fine, and it's the how that matters.
Diabetes is really just sugar ending up in the wrong places, so there isn't one drug for it. There's a drug for each place. This episode walks the whole body and picks up one tool at every stop. We start at the liver with metformin, the drug almost everyone gets first, then move to the fat and muscle with the glitazones, the pancreas with the sulfonylureas and meglitinides, the kidney with the SGLT2 inhibitors, and the gut with the alpha-glucosidase inhibitors. Then we finish with insulin itself, the one that replaces what's missing instead of nudging what's left. Every drug gets explained by
Raw milk is having a moment. The current HHS Secretary drinks it, wants more people to have access to it, and the internet is full of claims about how it's more natural and better for you. So we went and checked. This one's about what the research actually says, why we started heating milk in the first place, and what the "good old days" leave out.
Every blockbuster diabetes drug of the last decade hijacks the same trick: a hormone your gut releases the second food shows up, telling your pancreas to get ready. This episode is the why behind that hormone. We start with the incretin system itself, GLP-1 and GIP, then build out the two drug strategies that grew from it: the "-tide" injectables that mimic the hormone, and the "-gliptin" pills that stop your body from breaking it down. Then tirzepatide, the newer drug pulling two levers at once. By the end, the side effects, the contraindications, even who these drugs are right for, all of it
Four cancers that all start the same way: a thyroid nodule. From there the stories split. The young woman with childhood radiation and lymph nodes in the neck. The middle-aged patient whose FNA can't make the diagnosis. The patient with diarrhea, a family history, and a tumor that secretes calcitonin. And the elderly patient with the rock-hard mass and a six-month prognosis. Season 2 premiere.
Trauma doesn't just live in the person who experienced it. It changes the brain in real, measurable ways, and it echoes through families in ways we are only beginning to understand. In this episode, we get into what trauma actually does to the brain, what it can develop into over time, and the big question everybody asks but nobody answers honestly: can trauma actually pass from one generation to the next. We walk through the science, but we keep it real. The brain regions that get reshaped. The way a child's nervous system learns to read a room before they ever read a book. The cycle of harm
Four diseases. Three labs. One framework. Primary is the gland gone rogue. Secondary is the gland doing its job in a CKD patient. Tertiary is secondary that went too far. And FHH is the broken calcium sensor that mimics primary but won't respond to surgery. Plus the urine calcium trick that keeps you from operating on the wrong patient. Season 1 finale.
Seven dementias, seven discriminators. The fast one with myoclonus. The triad where gait comes first. The stepwise decline with infarcts on imaging. The cluster of hallucinations and parkinsonism within a year. The timing rule that separates the two Lewy body diseases. The reversible one. And the default everyone else gets compared to. Plus the antipsychotic warning every clinician needs to know cold.
Five enzymes. Five completely different bedside pictures. From a floppy baby with a massive heart, to a kid headed for cirrhosis, to a young adult crashing every workout with cola-colored urine. This episode walks through the five glycogen storage diseases and gives you a five-question decision tree that sorts any one of them at the bedside.
The cardiologist walked into my hospital room and asked if I was ready to go home before saying hello. What happened next, and what it taught me about how doctors talk to patients, and how patients can talk back.
May is Mental Health Awareness Month, and this episode is a wider look at what mental illness actually feels like from the inside. We walk through depression, anxiety, OCD, PTSD, bipolar, postpartum mental health, and eating disorders. Not textbook definitions, just real conversation about what these conditions look like when you're living them. We bust some of the myths that are still doing damage, like the idea that therapy is just venting, that medication changes who you are, or that you have to be in crisis to deserve help. We talk about medical conditions that can mimic mental illness, in
Five vaccines. Five different ways to teach the immune system. In this episode we walk through every vaccine type you need to know for Step 1. Live attenuated, killed and inactivated, subunit, toxoid, and mRNA. What each one actually is, how it works, which diseases it covers, and the catch that comes with it. Plus the mnemonics that make them stick, the classification traps that show up on questions, and the reason all five exist instead of just one.
Ehlers-Danlos Syndrome, or EDS, is a group of connective tissue disorders that affect way more than just the joints. In this episode, we get into what EDS actually is, the three main subtypes you'll hear about most, and why so many people spend years getting the wrong answers before they finally get the right one. We talk about the conditions that ride along with EDS, like POTS, MCAS, and GI issues, plus the strong overlap with autism and ADHD. We get into how women get dismissed at higher rates and why that matters. Then we shift into what actually helps, what good treatment looks like, and h
ARFID isn't anorexia. It isn't bulimia. And it isn't just picky eating. In this episode, we get into what ARFID actually is, why old school approaches like clean your plate can do real harm, and what real treatment looks like, including CBT and exposure therapy. We finish with how to be kind to people with ARFID and a section just for the parents. If you have ARFID, love someone who does, or have ever been called picky in a way that didn't sit right, this one's for you.
Six diseases. Same picture. Hematuria, hypertension, swelling, and red blood cell casts in the urine. This episode walks through the six types of nephritic syndrome and how to tell them apart based on the patient, the timing, and what's happening under the microscope.
One bug. Four faces. Same treatment every time. This episode walks through the four stages of syphilis, plus the bonus pearl that catches a lot of people off guard. Primary, secondary, tertiary, and congenital, with a single thread tying them all together: the answer is always penicillin.
Six tumors. Three benign, three malignant. One organ that almost never tells you what's happening inside it. This episode walks through the six liver tumors and how to tell them apart based on who the patient is and what the imaging shows.
Four bleeds. Four CT shapes. One framework. This episode walks through the four types of intracranial hemorrhage, where blood ends up in different compartments of the brain depending on what tore. Epidural, subdural, subarachnoid, and intraparenchymal. By the end, you'll be able to look at any head CT vignette and know exactly which one you're looking at.
Today we're doing the four hypertensive disorders of pregnancy. I'm going to walk through them in order, easiest to ugliest, and by the end you should be able to get handed any vignette and sort it into the right bucket.
5 USMLE Step 1 style questions and breaking down the answer choices!
