Medical News Podcast

The Medical News Podcast by PeerDirect delivers news and interviews with clinical thought leaders and researchers to keep you informed of the latest breakthroughs, guidelines, and insights in your specialty. Designed for clinicians with stories selected by the PeerDirect editorial board. Visit us at peerdirect.com to sign-up for our newsletter.

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Episodes 299

PRIME-PPF: Biomarkers, Imaging, and ILD Treatment
yesterday · 7:31
Drs. Montesi and Martinez discuss how the emerging PRIME-PPF clinical cohort study and biomarker research will sharpen definitions of disease progression and transform treatment decisions in non-IPF ILD. They highlight the potential for clinicians to use integrated data (eg, symptoms, physiology, imaging, and circulating proteomic signatures) to initiate antifibrotic and combination therapies earlier, tailoring them to individual patients while also balancing side effects and standard immunomodulatory care.
Could personalized mRNA therapy be moving closer to clinical practice after positive phase 3 results in melanoma?
2d ago · 5:13
This episode highlights three clinically relevant developments: positive phase 3 results for individualized mRNA neoantigen therapy plus pembrolizumab after melanoma surgery, emerging MRI and AI approaches that may identify Alzheimer’s-related brain changes years earlier, and substantial LDL-C treatment gaps under the 2026 ACC/AHA dyslipidemia guideline. Together, the findings underscore advances in precision oncology, early neurodegenerative risk detection, and cardiovascular prevention.
Bringing It to the Bedside: Humanistic Care and Reproductive Health in Lupus
3d ago · 10:54
Drs. Wise and Stohl discuss how truly effective care depends not just on advanced therapies, but also on humanistic, honest conversations about reproductive health and medication adherence. They highlight that patients—especially women of childbearing age and those from disadvantaged backgrounds—need ongoing, nuanced dialogue and genuine rapport in addition to a prescription.
CAR T-Cell Therapy in CLL and Richter’s Transformation: Emerging Evidence and Practical Integration Into Clinical Practice
4d ago · 10:57
Drs. Ghia and Scarfò discuss how CAR T-cell therapy is emerging as a powerful option for high-risk CLL and Richter transformation, especially in patients who have failed BTK and BCL-2 inhibitors. They stress that achieving deep remissions, choosing the right patients, and referring early to specialized centers are critical to improving outcomes.
ACC 2026 Highlights: New Frontiers in Myosin Inhibition
5d ago · 12:32
Drs. de Feria and Owens review emerging data on cardiac myosin inhibitors for obstructive hypertrophic cardiomyopathy, from adolescent therapy to interruption and reinitiation of treatment. They highlight impacts on left ventricular outflow tract gradients, symptoms, biomarkers, and practical periprocedural management.
Safety of Intravitreal Injections
8d ago · 11:28
Drs. Mehta and Garg cover how to counsel patients about intravitreal injections, emphasizing communication strategies, comfort measures, and the crucial role of office staff in creating a reassuring experience. They also review long-term treatment adherence, infection risk mitigation, and evidence supporting alcohol-free chlorhexidine as a better-tolerated antiseptic than povidone-iodine.
As U.S. measles cases reach a 35-year high, the White House is trying to overhaul the childhood vaccine schedule—including plans to split MMR. How are leading medical societies reacting?
9d ago · 5:37
This episode examines controversial proposed changes to the U.S. childhood vaccine schedule amid a 35-year high in measles cases, along with medical society concerns about evidence and access. It also reviews positive phase 3 topline data for lysergide in generalized anxiety disorder, updated colorectal cancer screening guidance that now includes blood-based testing, and the CHIPS trial showing refrigerated platelets may safely extend storage to 21 days and improve access in rural and community hospitals.
Personalized Therapy in Atopic Dermatitis
12d ago · 9:44
Drs. Cices and Ungar discuss how they personalize biologic therapy for atopic dermatitis, especially in older adults, young patients, and those with complex comorbidities. They compare targeted biologics and JAK inhibitors, highlighting options like dupilumab, lebrikizumab, tralokinumab, and nemolizumab, and emphasize shared decision-making to align treatment with each patient’s lifestyle, comorbidities, and priorities.
Recognizing Type 2–High Asthma in the Clinic
15d ago · 10:08
Drs. Griffiths and Chase explain type 2–high asthma as a multisystem inflammatory disease that often coexists with conditions like allergic rhinitis, sinus disease with polyps, eczema, food allergies, and eosinophilic esophagitis. They emphasize the importance of recognizing type 2–high patterns through history and biomarkers; they also discuss the roles of multidisciplinary care, optimized inhaler use, reduced steroid exposure, and targeted biologic therapy when asthma remains uncontrolled.
As children return to school, could a biologic offer a safer and more practical way to manage multiple food allergies?
16d ago · 5:16
This episode examines new evidence comparing omalizumab with multiallergen oral immunotherapy for multiple food allergies, finding that omalizumab may offer better tolerability and treatment completion. It also reviews the ICECAP trial, which found no neurologic benefit from extending hypothermia after out-of-hospital cardiac arrest, and the SOLARIS trial, in which high-dose vitamin D3 did not improve outcomes in metastatic colorectal cancer.
Systems of Care After Ischemic Stroke and Secondary Stroke Prevention
18d ago · 12:39
Drs. Denny and Berger review how to optimize continuity of care and secondary stroke prevention as patients transition from hospital to home. They emphasize multidisciplinary outpatient stroke care, psychosocial needs, and safe return to community roles.
Hypertrophic Cardiomyopathy Obstruction Is Dynamic: How to Avoid Missing Latent LVOTO
22d ago · 9:32
Drs. Owens and de Feria discuss strategies to identify latent LVOTO in hypertrophic cardiomyopathy and avoid misclassifying patients as non‑obstructive. They review diagnostic echo maneuvers and outline evolving pharmacologic and interventional treatment pathways.
Are NaV1.8 inhibitors becoming an important new option for acute pain?
23d ago · 5:21
This episode reviews four clinically relevant studies: emerging NaV1.8 inhibitors as promising non-opioid therapies for acute pain, a once-weekly oral HIV maintenance regimen demonstrating noninferiority to daily treatment, evidence supporting abbreviated dual antithrombotic therapy after PCI in selected patients with atrial fibrillation, and a meta-analysis showing limited benefit of oral antihistamines for atopic dermatitis. Together, these studies highlight evolving evidence that may influence prescribing practices across multiple specialties
Reset vs Management: Debate for Treatment-Refractory Lupus Nephritis
24d ago · 11:51
Drs. Wise and Stohl discuss emerging cell therapies for refractory lupus, focusing on the CASTLE trial and its promising early results in resetting the immune system and achieving treatment-free remission. They balance enthusiasm with caution, stressing unknown long-term safety, practical, and logistical barriers, and the need to avoid overselling these therapies as a near-term cure.
Beyond the Pain: Migraine, Depression, and Anxiety in Clinical Practice
25d ago · 13:32
Drs. Buse and Bonakdar discuss how migraine is deeply intertwined with mental health conditions such as depression and anxiety, forming a powerful “multimorbidity” cluster that can intensify pain, disability, and stigma. By combining compassionate, stigma-free communication with evidence-based tools—from simple screening questions (such as PHQ-9, GAD-7, and anhedonia prompts) to pharmacologic and behavioral therapies—clinicians can meaningfully improve both migraine and mood outcomes for their patients.
From Early Intervention to Holistic Care: ATTR-CM Updates From ACC 2026
26d ago · 13:34
Drs. Alexander and Witteles discuss emerging data on transthyretin amyloid cardiomyopathy therapies, emphasizing early initiation of disease-modifying treatment and the prognostic value of functional measures such as the six-minute walk test. They also highlight observational evidence that aggressive cardiometabolic management, including use of newer antidiabetic agents, may further reduce residual cardiovascular risk in patients with ATTR-CM and diabetes.
PPF Classifications: Where Are We Now?
29d ago · 8:15
Drs. Montesi and Martinez explore how to define and monitor PPF, especially in non-IPF ILD. They describe advances in recognizing progression and the use of antifibrotic therapy, while also highlighting ongoing controversy over exact criteria and emphasizing the need to combine symptoms, lung function (FVC, DLCO), and CT imaging for careful, regular follow-up.
Could Cyclospora explain your patient's persistent summer diarrhea?
1mo ago · 5:10
This episode reviews the ongoing Cyclospora outbreak and emphasizes the importance of targeted diagnostic testing for patients with persistent summer diarrhea, highlights evidence supporting family-based behavioral treatment for childhood obesity in primary care, and examines a new meta-analysis comparing the cardiometabolic benefits of GLP-1 receptor agonists beyond weight loss. Together, these studies reinforce practical, evidence-based approaches to infectious disease, pediatric obesity, and personalized obesity management.
Systems of Care and Patient Flow for Patients With Retinal Disease
1mo ago · 11:57
Drs. Garg and Mehta focus on challenges and solutions in providing retinal care for patients—especially those with diabetes—including barriers like socioeconomic factors, transportation, insurance, and the need for coordinated, team-based care with other medical specialists. They highlight initiatives such as diabetic eye screening days and emerging technologies like tele-ophthalmology, home OCT, and AI-driven screening and monitoring to improve access, continuity of care, and visual outcomes.
Targeting the OX40 Pathway in Atopic Dermatitis: Lessons Learned From Recent Clinical Data
1mo ago · 9:27
Drs. Bunick and Shahriari discuss the emerging role of the OX40/OX40L pathway in atopic dermatitis, highlighting how targeting antigen-specific T cells may rebalance the immune system and potentially induce durable, off-drug remission. They review promising phase 2 and 3 data for agents like rocatinlimab and amlitelimab, emphasize encouraging safety profiles, and explore future innovations such as combination and bispecific approaches to improve both speed and durability of disease control.
Secondary Prevention of Non-Cardioembolic Ischemic Stroke
1mo ago · 9:24
Drs. Berger and Denny discuss modern secondary prevention after non-cardioembolic ischemic stroke, focusing on short dual antiplatelet courses and individualized agent choice. They emphasize structured vascular risk management and look ahead to newer, safer antithrombotic options.
Minimal Residual Disease (MRD) in CLL: Clinical Utility and Practicality
1mo ago · 17:35
Drs. Chang and Cohen discuss how MRD has become an important tool for assessing how well patients with CLL respond to treatment, beyond what standard blood tests can show. They conclude that although MRD is very useful in research and can help inform conversations with patients, it is not yet clear how or whether it should routinely guide real-world treatment decisions.
Should some patients remain on dual antiplatelet therapy beyond one year after multivessel PCI?
1mo ago · 6:24
This episode reviews new evidence supporting extended DAPT beyond one year for selected patients after multivessel PCI, the role of MRD-guided decisions for maintenance lenalidomide in multiple myeloma, adjuvant ensartinib for resected ALK-positive NSCLC, and emerging data on semaglutide and combination therapy for MASH-related cirrhosis. The studies highlight how precision medicine continues to refine treatment duration, biomarker-driven care, and therapeutic selection across multiple specialties.
How easy is it to get prescription GLP-1s online?
1mo ago · 5:42
This episode reviews new evidence on online GLP-1 prescribing practices, aspirin-only thromboprophylaxis after hip and knee arthroplasty, unexpected protection against gonorrhea from meningococcal B vaccination, and a cannabinoid formulation for agitation in advanced dementia. The studies highlight evolving approaches to obesity care, postoperative management, infectious disease prevention, and palliative dementia treatment with important implications for clinical practice.
Approaches to Pharmacotherapy in ILD, IPF, and PPF
1mo ago · 12:48
Drs. Martinez and Montesi discuss how treatment for ILD, IPF, and PPF has shifted from “nothing we can do” to a complex, rapidly expanding toolbox that now includes multiple antifibrotic options and emerging combination strategies. They stress that these drugs slow progression but don’t cure disease, so real-world decisions hinge on side effects, quality of life considerations, patient goals, and the often frustrating realities of insurance coverage and cost.

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Medical News Podcast

Episodes 299

PRIME-PPF: Biomarkers, Imaging, and ILD Treatment

Could personalized mRNA therapy be moving closer to clinical practice after positive phase 3 results in melanoma?

Bringing It to the Bedside: Humanistic Care and Reproductive Health in Lupus

CAR T-Cell Therapy in CLL and Richter’s Transformation: Emerging Evidence and Practical Integration Into Clinical Practice

ACC 2026 Highlights: New Frontiers in Myosin Inhibition

Safety of Intravitreal Injections

As U.S. measles cases reach a 35-year high, the White House is trying to overhaul the childhood vaccine schedule—including plans to split MMR. How are leading medical societies reacting?

Personalized Therapy in Atopic Dermatitis

Recognizing Type 2–High Asthma in the Clinic

As children return to school, could a biologic offer a safer and more practical way to manage multiple food allergies?

Systems of Care After Ischemic Stroke and Secondary Stroke Prevention

Hypertrophic Cardiomyopathy Obstruction Is Dynamic: How to Avoid Missing Latent LVOTO

Are NaV1.8 inhibitors becoming an important new option for acute pain?

Reset vs Management: Debate for Treatment-Refractory Lupus Nephritis

Beyond the Pain: Migraine, Depression, and Anxiety in Clinical Practice

From Early Intervention to Holistic Care: ATTR-CM Updates From ACC 2026

PPF Classifications: Where Are We Now?

Could Cyclospora explain your patient's persistent summer diarrhea?

Systems of Care and Patient Flow for Patients With Retinal Disease

Targeting the OX40 Pathway in Atopic Dermatitis: Lessons Learned From Recent Clinical Data

Secondary Prevention of Non-Cardioembolic Ischemic Stroke

Minimal Residual Disease (MRD) in CLL: Clinical Utility and Practicality

Should some patients remain on dual antiplatelet therapy beyond one year after multivessel PCI?

How easy is it to get prescription GLP-1s online?

Approaches to Pharmacotherapy in ILD, IPF, and PPF

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Episodes 299

PRIME-PPF: Biomarkers, Imaging, and ILD Treatment

Could personalized mRNA therapy be moving closer to clinical practice after positive phase 3 results in melanoma?

Bringing It to the Bedside: Humanistic Care and Reproductive Health in Lupus

CAR T-Cell Therapy in CLL and Richter’s Transformation: Emerging Evidence and Practical Integration Into Clinical Practice

ACC 2026 Highlights: New Frontiers in Myosin Inhibition

Safety of Intravitreal Injections

As U.S. measles cases reach a 35-year high, the White House is trying to overhaul the childhood vaccine schedule—including plans to split MMR. How are leading medical societies reacting?

Personalized Therapy in Atopic Dermatitis

Recognizing Type 2–High Asthma in the Clinic

As children return to school, could a biologic offer a safer and more practical way to manage multiple food allergies?

Systems of Care After Ischemic Stroke and Secondary Stroke Prevention

Hypertrophic Cardiomyopathy Obstruction Is Dynamic: How to Avoid Missing Latent LVOTO

Are NaV1.8 inhibitors becoming an important new option for acute pain?

Reset vs Management: Debate for Treatment-Refractory Lupus Nephritis

Beyond the Pain: Migraine, Depression, and Anxiety in Clinical Practice

From Early Intervention to Holistic Care: ATTR-CM Updates From ACC 2026

PPF Classifications: Where Are We Now?

Could Cyclospora explain your patient's persistent summer diarrhea?

Systems of Care and Patient Flow for Patients With Retinal Disease

Targeting the OX40 Pathway in Atopic Dermatitis: Lessons Learned From Recent Clinical Data

Secondary Prevention of Non-Cardioembolic Ischemic Stroke

Minimal Residual Disease (MRD) in CLL: Clinical Utility and Practicality

Should some patients remain on dual antiplatelet therapy beyond one year after multivessel PCI?

How easy is it to get prescription GLP-1s online?

Approaches to Pharmacotherapy in ILD, IPF, and PPF